Based on the clinical information, my guess is a HTLV-1 T-cell lymphoma. Theses cells are of course typically CD3+/CD4+/CD25+/CD7±. Te-Chih Liu, MD Haematology NUH, Singapore >The patient is a 48 yr. old male, HIV positive, with osteolytic lesions >in the head, cervical vertebrae and ribs, hypercalcemic and with a >pleural effusion. > >We received the pleural effusion, which showed microscopically many >medium to large sized cells with basophilic cytoplasms, somewhat >eccentric nuclei and prominentI have always found flow analysis of pleural or ascitic fluid a little unpredictable. Many times, the analysis is un-characteristic and the diagnosis has to be made on other information. The description of the morphology of the cells can go for mesothelial cells and the immuno-type would not be too inconsistent with this. The distinction from lymphoma cells is however primarily by morphology. pale golgi. There were some small >vacuoles but no granules. > >Because of some reported geographical exposure and the bone lesions, we >wondered about a HTLV I T- cell lymphoma. > >Light scatter analysis showed a medium to large sized cell population >with a little increased ssc. The immunophenotype of these cells was:
This archive was generated by hypermail 2b29 : Wed Apr 03 2002 - 11:53:12 EST