I would appreciate any input anyone might have into this unusual case. The patient is a 48 yr. old male, HIV positive, with osteolytic lesions in the head, cervical vertebrae and ribs, hypercalcemic and with a pleural effusion. We received the pleural effusion, which showed microscopically many medium to large sized cells with basophilic cytoplasms, somewhat eccentric nuclei and prominent pale golgi. There were some small vacuoles but no granules. Because of some reported geographical exposure and the bone lesions, we wondered about a HTLV I T- cell lymphoma. Light scatter analysis showed a medium to large sized cell population with a little increased ssc. The immunophenotype of these cells was: CD45 bright CD3 neg CD4 98% bright CD8 neg CD5 neg CD19 38% CD10 neg HLA DR neg CD2 neg CD7 neg CD13 neg CD14 neg CD15 neg CD33 neg CD34 neg CD24 neg Glycophorin neg CD9 85% CD20 neg CD11b neg CD61 neg cCD3 neg CD22 neg CD38 100% bright CD11c neg CD56 neg cKappa neg cLambda neg The patient has no serum protein abnormalities. Brent Dorsett Lenox Hill Hospital -- NYC
This archive was generated by hypermail 2b29 : Wed Apr 03 2002 - 11:53:12 EST