Richard Meister wrote: > Hello, everyone: > I have two questions re: apoptosis that came up during a recent consult on > the subject. > 1. What is the best positive control to use; i.e., an easy-to-grow cell > line that can be reliably and predictably induced into apoptosis? (I seem > to recall a thread on this question some time ago, but I couldn't find it in > the archives.) HL-60 serves well as an apoptosis-inducable positive control. > 2. How should one pronounce "apoptosis"? When I first heard the term > (probably 10 years ago), the second "p" was silent (A-pO-tO-sis). Since > then, I have increasingly heard the second "p" pronounced (A-pop-tO-sis). > And, I can't find the word in a dictionary. > I think the latter is more accurate. I don't know if the term apoptosis was first used here, but Kerr et.al, suggested " 'ap'tosis " as the proper pronunciation thus dropping the "op" entirely. (Kerr, J.F.R., Wyllie, A.H., Currie, A.R. A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257 (1972).) MAK. -- Mark A. KuKuruga, Managing Director University of Michigan Core Flow Cytometry kukuruga@medmail.med.umich.edu
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