Re: Cytoplasmic IgM in adults

From: Anna Porwit-MacDonald (Anja.Porwit@mb.ks.se)
Date: Fri Feb 05 1999 - 09:41:04 EST


Hi,
The pre-B ALL (cyt.IgM+) are very rare in adults. The most important
negative prognostic factor in adult ALL is the presence of 9;22
translocation (Ph+) and these are usually sc "common"  ALL.
Best wishes
Anna

At 09.44 1999-02-03 -0500, you wrote:
>
>Dear Flow collegues,
>We are currently using the presence of cIgM to differentiate precursor B-ALL
>or pre-pre B-ALL (cIgM neg) from pre-B ALL (cIgM pos) in pediatric patients.
>Apparently pediatric patients with pre B-ALL do worse than patients with
>precursor B-ALL (pre-pre B ALL).  Does the same prognosis apply to adults
>with B-ALL?  The literature is not quite clear on this issue from what I
>remember.
>Thanks for your help
>Andrea Illingworth 
>Dahl-Chase Diagnostic Services/Flow Cytometry
>333 State Street
>Bangor, Maine 04401
>(207)990-4855
>
>
>
Anna Porwit-MacDonald
Heamatopathology Lab.
Department of Pathology
Karolinska Hospital, Stockholm
anpo@mb.ks.se
tel.:+46-851775863
fax.:+46-851775843



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