For those who are interested, a very detailed analysis of NK associated immunophenotypes can be found in Leukemia and Lymphoma Vol 2:111-126, 1990 by Stephen J Richards and Colin Stephen Scott. Regards Sean P. McDonough DVM PhD At 05:05 PM 1/26/99 +0000, you wrote: > >Hi Mary, > >Yes, we have seen populations with this immunophenotype (CD4+, CD57+ >T-cells) occasionally in reactive conditions. They reportedly can be >expanded in patients with rheumatoid arthritis, some hematologic >malignancies (including CLL and hairy cell leukemia), and following solid >organ transplantation. They have a cytotoxic activity. We recently have >seen one case of presumed LGL-leukemia with this immuunophenotype, as has >been reported in the literature. > >Brent Wood MD PhD >Associate Director of Hematology Laboratory >University of Washington Medical Center >EM: woodbl@u.washington.edu Phone: (206) 548-6199 Fax: (206) 548-6189 > >---------- >>From: Maryalice Stetler-Stevenson <stetler@box-s.nih.gov> >>To: Cytometry Mailing List <cytometry@flowcyt.cyto.purdue.edu> >>Subject: Unusual case >>Date: Mon, Jan 25, 1999, 10:46 PM >> > >> >>Here's a weird one: >> >> 43 yo white male. 30.4%HCT, 625 K/UL plateets, WBC- 4.27 K/UL with >>44.3% polys, 12% lymphocytes, 26.5% monocytes, 14.8% eosinophils and 2.4% >>basophils. 96% of lymphocytes are T-cells. 92% of Lymphocytes are CD4+,CD3+ >>and 4 % CD8+,CD3+. This is the cute part- 45% are CD4+, CD57+, CD3+ >>T-cells. They are mostly CD7+ (15% CD7-,CD3+), all CD2+ and CD5+ (a >>slightly dim population noted). They are TCR alpha beta +, CD16-, CD38+, >>and HLADR- as well as negative for B-cell antigens. How often have you seen >>CD4+CD57+ T-cells? >> >> Maryalice >>Maryalice Stetler-Stevenson >>Director Flow Cytometry Unit >>Laboratory of Pathology, NCI, NIH >> >
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