Re: Unusual case

From: woodbl (woodbl@u.washington.edu)
Date: Tue Jan 26 1999 - 12:05:38 EST


Hi Mary,

Yes, we have seen populations with this immunophenotype (CD4+, CD57+
T-cells) occasionally in reactive conditions.  They reportedly can be
expanded in patients with rheumatoid arthritis, some hematologic
malignancies (including CLL and hairy cell leukemia), and following solid
organ transplantation.  They have a cytotoxic activity.  We recently have
seen one case of presumed LGL-leukemia with this immuunophenotype, as has
been reported in the literature.

Brent Wood MD PhD
Associate Director of Hematology Laboratory     
University of Washington Medical Center         
EM: woodbl@u.washington.edu  Phone: (206) 548-6199  Fax: (206) 548-6189

----------
>From: Maryalice Stetler-Stevenson <stetler@box-s.nih.gov>
>To: Cytometry Mailing List <cytometry@flowcyt.cyto.purdue.edu>
>Subject: Unusual case
>Date: Mon, Jan 25, 1999, 10:46 PM
>

>
>Here's a weird one:
>
> 43 yo white male. 30.4%HCT, 625 K/UL plateets, WBC- 4.27 K/UL with
>44.3% polys, 12% lymphocytes, 26.5% monocytes, 14.8% eosinophils and 2.4%
>basophils. 96% of lymphocytes are T-cells. 92% of Lymphocytes are CD4+,CD3+
>and 4 % CD8+,CD3+. This is the cute part- 45% are CD4+, CD57+, CD3+
>T-cells. They are mostly CD7+ (15% CD7-,CD3+), all CD2+ and CD5+ (a
>slightly dim population noted). They are TCR alpha beta +, CD16-, CD38+,
>and HLADR- as well as negative for B-cell antigens. How often have you seen
>CD4+CD57+ T-cells?
>
> Maryalice
>Maryalice Stetler-Stevenson
>Director Flow Cytometry Unit
>Laboratory of Pathology, NCI, NIH
>



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