Hi Mary, Yes, we have seen populations with this immunophenotype (CD4+, CD57+ T-cells) occasionally in reactive conditions. They reportedly can be expanded in patients with rheumatoid arthritis, some hematologic malignancies (including CLL and hairy cell leukemia), and following solid organ transplantation. They have a cytotoxic activity. We recently have seen one case of presumed LGL-leukemia with this immuunophenotype, as has been reported in the literature. Brent Wood MD PhD Associate Director of Hematology Laboratory University of Washington Medical Center EM: woodbl@u.washington.edu Phone: (206) 548-6199 Fax: (206) 548-6189 ---------- >From: Maryalice Stetler-Stevenson <stetler@box-s.nih.gov> >To: Cytometry Mailing List <cytometry@flowcyt.cyto.purdue.edu> >Subject: Unusual case >Date: Mon, Jan 25, 1999, 10:46 PM > > >Here's a weird one: > > 43 yo white male. 30.4%HCT, 625 K/UL plateets, WBC- 4.27 K/UL with >44.3% polys, 12% lymphocytes, 26.5% monocytes, 14.8% eosinophils and 2.4% >basophils. 96% of lymphocytes are T-cells. 92% of Lymphocytes are CD4+,CD3+ >and 4 % CD8+,CD3+. This is the cute part- 45% are CD4+, CD57+, CD3+ >T-cells. They are mostly CD7+ (15% CD7-,CD3+), all CD2+ and CD5+ (a >slightly dim population noted). They are TCR alpha beta +, CD16-, CD38+, >and HLADR- as well as negative for B-cell antigens. How often have you seen >CD4+CD57+ T-cells? > > Maryalice >Maryalice Stetler-Stevenson >Director Flow Cytometry Unit >Laboratory of Pathology, NCI, NIH >
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