Just a crazy guess, but microglial cells should have this surface phenotype, and be absolutely huge. I'm not sure about trafficking of these cells (i.e. if they are just in the tissues of the brain, or if they can be found in CSF). If you look at them on a slide, I believe they would resemble a giant dendritic cell, with many processes emerging from a central body. good luck -- ----------------------------------------------- "Kids, you tried your best, and you failed miserably. The lesson is, never try." --Homer Simpson Keith Bahjat Graduate Assistant University of Florida College of Medicine Gainesville, Florida kbahjat@ufl.edu ---------- >From: Marc Jacobsen <jacobsen@mailer.uni-marburg.de> >To: Cytometry Mailing List <cytometry@flowcyt.cyto.purdue.edu> >Subject: CD4 positive but CD3 and CD14 and CD16 and TCRalpha/beta and TCRgamma/delta negative cells >Date: Mon, Jan 11, 1999, 12:46 PM > > > Dear colleagues, > > has anyone experience with such a cell type? We found it in the > cerebrospinal fluid of a patient suffering herpes enzephalitis. The cells > are up to 10-times bigger than T cells and express CD4 on their surface. > Maybe it is a kind of tumor cell? > > Thanks in advance > > Marc > Marc Jacobsen > MZ Nervenheilkunde - Neurologische Klinik mit Poliklinik > Rudolf-Bultmann-Str.8, 35039 Marburg, Germany, > Fax +49 6421 28 7055, Phone +49 6421 28 2678
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