We have just typed a child with the following immunophenotype. The blasts are postive(>90%) for CD45, HLA-DR, TdT, CD34 , CD19, CD22. CD10 = 60%, CD20= 47%. There are 40% CD33+CD7+ cells which by further double labelling are also CD10+. Negative for: CIg-mu, T markers, CD1a,CD2, CD3, Cyto CD3, CD5, Myeloid, CD13 and CD14. Myeloperoxidase stain is negative and the blasts look lymphoid :FAB ALL-L2. Cytogenetics not through yet. Is this a common ALL with CD33 expression (not uncommon of course) with abberant expression of CD7? I would be reluctant to call it mixed or biphenotyic. I have seen one reference which cited 3 cases of CD7 + common ALL but there was no myeloid antigen positivity. Feedback appreciated. thanks Jan Jan Nelson Molecular Haematology Department of Molecular Medicine The University of Auckland Phone: (+64)(9) 373-7599 ext 6381 Fax: (+64)(9) 373-7492
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