Dear Jan, During last four years we had 2 similar cases of childhood ALL showing coexpression of myeloid (one CD15 and one CD13) and CD7 markers together with a common ALL phenotype. The clinics and response to the first line treatment did not differ from what is usually seen in B-precursor ALL. Best wishes Anna Porwit-MacDonald At 13.14 1998-01-25 +1200, you wrote: > >We have just typed a child with the following immunophenotype. > >The blasts are postive(>90%) for CD45, HLA-DR, TdT, CD34 , CD19, CD22. CD10 >= 60%, CD20= 47%. There are 40% CD33+CD7+ cells which by further double >labelling are also CD10+. >Negative for: CIg-mu, T markers, CD1a,CD2, CD3, Cyto CD3, CD5, Myeloid, >CD13 and CD14. >Myeloperoxidase stain is negative and the blasts look lymphoid :FAB ALL-L2. >Cytogenetics not through yet. > >Is this a common ALL with CD33 expression (not uncommon of course) with >abberant expression of CD7? >I would be reluctant to call it mixed or biphenotyic. > >I have seen one reference which cited 3 cases of CD7 + common ALL but there >was no myeloid antigen positivity. >Feedback appreciated. >thanks >Jan > >Jan Nelson >Molecular Haematology >Department of Molecular Medicine >The University of Auckland >Phone: (+64)(9) 373-7599 ext 6381 >Fax: (+64)(9) 373-7492 > > > > Anna Porwit-MacDonald Heamatopathology Lab. Department of Pathology Karolinska Hospital, Stockholm anpo@mb.ks.se tel.:+46-851775863 fax.:+46-851775843
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