I would agree that MPO is not essential for a diagnosis of
biphenotypic acute leukemia, but the EGIL scoring recommendation
requires more than two points for myeloid antigens to call a case
biphenotypic. The expression of CD13 and CD33 are worth a total of 2
points and another myeloid marker would be needed before calling the
case biphenotypic.
Dan Arber
City of Hope
______________________________ Reply Separator _________________________________
Subject: Further CD45-negative acute leukemia
Author: <kcdol@samsung.co.kr > at INTERNET
Date: 1/14/98 11:20 PM
Dear flowers
I really appreciate for many experts' valuable comments
regarding CD45-negative acute leukemia.
Now that CD45-negative acute leukemia is not uncommon,
I would like to ask another question.
CD45, a protein tyrosine phosphatase, is known to be important
in regulation of cellular proliferation that is there any
evidence of the relation between leukemogenesis and CD45-negativity?
And today, we tried more monoclonal antibodies on those CD45-negative
leukemic cells that got following results;
MPO(-), CD45RA(-), CD45RB(-), CD45RO(strong positive)
on paraffing bone marrow section.
Another question I have is
Is MPO positivity essential to diagnose the acute biphenotypic leukemia?
Since EGIL working group suggested that in diagnosing acute biphenotypic
leukemia, MPO is the most valuable one but both CD13 and CD33 positivity
without MPO could be used as markers for acute biphenotypic leukemia.
Thanks again for your excellent comments.
---------------------------------------
---------------
Chang-Seok Ki, MD
3rd-year Resident
Dept of Clinical Pathology
Samsung Medical Center
Tel. 82-2-3410-2707
Fax. 82-2-3410-2719
E-mail. kcdol@samsung.co.kr
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