Dear flowers I really appreciate for many experts' valuable comments regarding CD45-negative acute leukemia. Now that CD45-negative acute leukemia is not uncommon, I would like to ask another question. CD45, a protein tyrosine phosphatase, is known to be important in regulation of cellular proliferation that is there any evidence of the relation between leukemogenesis and CD45-negativity? And today, we tried more monoclonal antibodies on those CD45-negative leukemic cells that got following results; MPO(-), CD45RA(-), CD45RB(-), CD45RO(strong positive) on paraffing bone marrow section. Another question I have is Is MPO positivity essential to diagnose the acute biphenotypic leukemia? Since EGIL working group suggested that in diagnosing acute biphenotypic leukemia, MPO is the most valuable one but both CD13 and CD33 positivity without MPO could be used as markers for acute biphenotypic leukemia. Thanks again for your excellent comments. --------------------------------------- --------------- Chang-Seok Ki, MD 3rd-year Resident Dept of Clinical Pathology Samsung Medical Center Tel. 82-2-3410-2707 Fax. 82-2-3410-2719 E-mail. kcdol@samsung.co.kr ------------------------------------------------------
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