Re: bone marrow

From: william nostrom (slickwilli@hotmail.com)
Date: Mon Jan 05 1998 - 11:13:29 EST


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>From: Cynthia Wyant <Wyant@mx.afrri.usuhs.mil>
>Subject: bone marrow
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>I am looking for help with analyzing mouse bone marrow for primitive 
myloid
>and lymphoid progenitors with FACS caliber.  Specifically is there a
>population within the total bone marrow that I need to focus on to 
optimize
>my instrument and to locate stem cells?  Are there any texts or
>instructional papers available on this subject?  Is anyone in the 
Virginia,
>Maryland, D.C. area working with mouse bone marrow and, if so, would 
you be
>willing to let me visit your lab?  I would love to see first hand your
>methods for manipulating bone marrow in the flowcyotmeter.
>
>Cyndi Wyant
>wyant@mx.afrri.usuhs.mil
>Armed Forces Radiobiology Research Institute
>Bethesda, MD
>

Cyndi, 
 Check out this paper, I think it might help you.

"Expression of Murine CD38 Defines a Population of Long-Term 
Reconstituting Hematoppoietic Stem Cells" Troy Randall, Blood, Vol 87, 
No 10 (May 15), 1996: pp4057-4067

If this doesn't help, I have Dr Randall's e-mail addy, and he may be 
able to answer your questions. 

Hope this helps,
Bill Nostrom
Trudeau Institute
Saranac Lake, NY 




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