Cytometrists, I have two interesting cases that I would like some help with. 1. The first patient appears to be a new acute leukemia with very large irregular cells. The bone marrow phenotypes CD13+,CD15+,CD33+,HLA DR+, CD45+(bright),CD14 My4+ but CD14 Mo2 negative. I would like to know others' experience with My4. Does it mark a more immature monocytoid cell? Would you call this myelomono- leukemia? 2. The second case is a patient with normal numbers of all cell types in the peripheral blood but with two clearly different populations of CD5+ cells--one very bright and the other dimmer but still positive. They do not dual stain with B cell markers. In 1993 the patient showed a T cell beta gene rearrangement. If we had not been aware of this we may not have worried so much about the staining. Has anyone noticed this pattern of CD5 reactivity? Thank you very much for your help. Michaeleen M. Collins
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