Maryalice Stetler-Stevenson wrote: > > I can't cite statistics but from our clinical experience, FMC7 is extremely > sensitive for mantle cell but not specific (many other lymphomas are FMC7 > positive). I have never had a real mantle cell lymphoma that was FMC7 > negative (most consistent with Mantle cell doesn't count as these are > usually something in between real mantle cell and something else). It is > useful in differentiating CD5+ neoplasms with the appropriate morphology. A > CD5+ neplasm that is FMC7+ and CD23- and has small lymphoid cells with > compact chromatin as well as some what cleaved nuclei is mantle cell. But > then of course, nothing stands alone in diagnosis of neoplasia. If you have > a specific example, what are the other antigens studied? > > Maryalice > > >HEY, > >DOES ANYONE KNOW THE SENSITIVITY AND SPECIFICITY OF FMC7 IN THE FACE OF A > >PICTURE THAT APPEARS TO REPRESENT INTERMEDIATE CELL (MANTLE CELL OR ZONE) > >LYMPHOMA IN HUMANS (FOR YOU PURISTS). THANKS SO MUCH, MELISSA L. BEAL, M.D. > > Maryalice Stetler-Stevenson > Director Flow Cytometry Unit > Laboratory of Pathology, NCI, NIH MaryAlice, Should you run FMC7 if you have cd19+, cd23-/cd5+ lymphoma? Our pathologist, when I approached him with this, believes it isn't necessary. You already, if the histology agrees, have a mantle zone presentation without FMC7 positivity. For our lymphoma panels we run cd3/cd19, cd5, cd10, cd23, kappa, lambda for B, appropriate T markers if not B. thanks, hugh johnson flow lab guy st vincent infirmary medical center little rock, ar
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