I can't cite statistics but from our clinical experience, FMC7 is extremely
sensitive for mantle cell but not specific (many other lymphomas are FMC7
positive). I have never had a real mantle cell lymphoma that was FMC7
negative (most consistent with Mantle cell doesn't count as these are
usually something in between real mantle cell and something else). It is
useful in differentiating CD5+ neoplasms with the appropriate morphology. A
CD5+ neplasm that is FMC7+ and CD23- and has small lymphoid cells with
compact chromatin as well as some what cleaved nuclei is mantle cell. But
then of course, nothing stands alone in diagnosis of neoplasia. If you have
a specific example, what are the other antigens studied?
Maryalice
>HEY,
>DOES ANYONE KNOW THE SENSITIVITY AND SPECIFICITY OF FMC7 IN THE FACE OF A
>PICTURE THAT APPEARS TO REPRESENT INTERMEDIATE CELL (MANTLE CELL OR ZONE)
>LYMPHOMA IN HUMANS (FOR YOU PURISTS). THANKS SO MUCH, MELISSA L. BEAL, M.D.
Maryalice Stetler-Stevenson
Director Flow Cytometry Unit
Laboratory of Pathology, NCI, NIH
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