Re: double label for dendritic cells and MVE virus antigen

From: Paul J. Jansen (zinetti@acpub.duke.edu)
Date: Tue Jun 10 1997 - 10:56:11 EST


Does this mean that there is an Ab against murine CD83 available??
Thanx.
Paul J Jansen


On Mon, 9 Jun 1997, Kevin G Waddick wrote:

> Date: Mon, 9 Jun 1997 17:24:57 -0500 (CDT)
> From: Kevin G Waddick <waddi002@maroon.tc.umn.edu>
> To: Cytometry Mailing List <cytometry@flowcyt.cyto.purdue.edu>
> Cc: Cytometry Mailing List <cytometry@flowcyt.cyto.purdue.edu>
> Subject: Re: double label for dendritic cells and MVE virus antigen
> 
> 
> 
> If the infected cells co-express HLA-DR and CD83, they are dendritic cells.
> 
> Kevin G. Waddick, Ph.D.
> Staff Scientist
> Hughes Institute
> 2685 Patton Road
> Roseville, Minnesota 55113
> (612) 628-0598
> (612) 628-9891  Fax
> 
> On Mon, 9 Jun 1997, Leanne Sammels wrote:
> 
> > 
> > Hello,
> > 
> > I'm not sure that this is the right place to post this question
> > but here goes. We have used in situ hybs to localise Murray
> > Valley encephalitis virus RNA in the lymph nodes of mice 
> > infected IP with MVE. Only a small population of cells 
> > within the lymph node are positive for viral RNA and the 
> > morphology suggests it may be the follicular dendritic 
> > cells. I am interested in using flow cytometry to analyse 
> > infected lymph node cell suspensions(or maybe just 
> > peritoneal washouts?)to see if it is the dendritic cells 
> > which are replicating virus or if other cell populations 
> > are also involved in viral replication. Is this feasible? 
> > and if so can anyone recommend some publications which 
> > would be helpful. I'm sure it is quite obvious by now 
> > that I have had no cytometry experience whatsoever. Any 
> > advice would be appreciated.
> > Kind regards,
> > 
> > Lee Sammels
> > Dr Leanne Sammels
> > Department of Microbiology
> > University of Western Australia
> > Nedlands WA 6009
> > 
> > Phone: 08 9346 4872
> > Fax:   08 9346 2912
> > 
> 



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