CD14 My4 vs. Mo2
Michaeleen M. Collins (Michaeleen.M.Collins@Lahey.Hitchcock.ORG)
Wed, 13 Aug 1997 13:02:22 +0000
Cytometrists,
I have two interesting cases that I would like some help with.
1. The first patient appears to be a new acute leukemia with very
large irregular cells. The bone marrow phenotypes CD13+,CD15+,CD33+,HLA DR+,
CD45+(bright),CD14 My4+ but CD14 Mo2 negative.
I would like to know others' experience with My4. Does it mark a
more immature monocytoid cell? Would you call this myelomono-
leukemia?
2. The second case is a patient with normal numbers of all cell
types in the peripheral blood but with two clearly different
populations of CD5+ cells--one very bright and the other dimmer but
still positive. They do not dual stain with B cell markers. In
1993 the patient showed a T cell beta gene rearrangement. If we had
not been aware of this we may not have worried so much about the
staining. Has anyone noticed this pattern of CD5 reactivity?
Thank you very much for your help.
Michaeleen M. Collins