CD29

Integrin b1-chain

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
4B4LDC9LDH8 (4B4)	Purified	100 tests	Freeze-dried	COULTER CLONE		6603113
IgG1 (mouse)	FITC	100 tests	Freeze-dried	COULTER CLONE		6603109
	RD1	100 tests	Liquid	COULTER CLONE		6603177
K20	Purified	0.2 mg	Freeze-dried			IM1151
IgG2a (mouse)	Purified	100 tests	Liquid	IOTest		IM0790
	FITC	100 tests	Liquid	IOTest		IM0791
Lia1/2	Purified	0.2 mg	Freeze-dried			IM1598
IgG1 (mouse)
CYTO-STATS

CD29 is the integrin b1 chain which is expressed as a heterodimer non-covalently associated with the integrin a subunits:1 to 6 (CD49a to CD49f) also known as Very Late Antigens (VLA). It is also called platelet GPIIa. It is a receptor of fibronectin. The antigen mediates cellular adhesion. This glycoprotein complex has a molecular weight of 130 kDa. It has broad cellular reactivity but is not expressed by erythrocytes. In normal peripheral blood it is found on a subset of CD4+ and CD8+ T lymphocytes and on a minority of B cells. The inducer/helper subpopulations of CD4+ lymphocytes coexpress CD4 and CD29. K20 is a non blocking antibody in CD29 mediated adhesion but Lia1/2 and 4B4 are blocking antibodies. 4B4 and K20 antibodies were evaluated during the Third International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu