CD22

B CELLS

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
HD239 (B3)	Purified	100 tests	Freeze-dried	COULTER CLONE		6603613
IgG2b (mouse)
* SJ10.1H11	Purified	0.2 mg	Freeze-dried			IM0715
IgG1 (mouse)*TH*	Purified	100 tests	Liquid	IOTest		IM0716
	FITC	100 tests	Liquid	IOTest		IM0779
	PE	100 tests	Liquid	IOTest		IM1835
CYTO-STATS

The CD22 antigen (BL-CAM) is a transmembrane glycoprotein of the immunoglobulin superfamily. It may be expressed as two different isoforms: the a form (130 kDa) and the b form (140 kDa). It is a B cell restricted antigen expressed in the cytoplasm of B cell progenitors and on the surface of mature B cells. CD22 expression is lost after B cell activation, prior to the plasma cell stage. It is absent from peripheral blood T cells, granulocytes, monocytes. B3 antibody binds to an epitope located within the first Ig-like domain of CD22 antigen. HD239 (B3) antibody was evaluated during the Fourth International Workshop on Human Leukocyte Differentiation Antigens. Workshop. SJ10.1H11 antibody was evaluated during the Third Workshop.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu