CD22
B CELLS
The CD22 (B3) antigen is a transmembrane glycoprotein of the immunoglobulin superfamily. It is likely to be expressed as two different isoforms: the a form (130 kDa) and the b form (140 kDa). It is a B cell restricted antigen expressed in the cytoplasm of B cell progenitors and on the surface of mature B cells. CD22 expression is lost after B cell activation prior to the plasma cell stage. It is absent from peripheral blood T cells, granulocytes, monocytes. HD239 antibody binds to an epitope located within the first Ig-like domain of CD22 antigen. It was characterized during the Fourth International Workshop on Human Leukocyte Differentiation Antigens.
© Coulter International Corporation, 1996. All rights reserved. Copyrights and Trademarks
Products are available FOR RESEARCH USE ONLY (RUO). Unless indicaed FOR IN VITRO DIAGNOSTIC USE (IVD)
CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories
and distributed free of charge as an educational service to the cytometry community.
If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL,
Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu
EMAIL robinson@flowcyt.cyto.purdue.edu
