CD14
MONOCYTES
The CD14 antigen is a glycosyl-phosphatidylinositol-linked single-chain surface membrane glycoprotein with a molecular weight of 53-55 kDa. It functions as a high affinity receptor for the complex of LipoPolySaccharide (LPS) and the LPS-Binding Protein (LBP). It is found on cells of myelomonocytic lineage. CD14 antigen is strongly expressed on monocytes, macrophages, and weakly on neutrophils. It is also weakly expressed on B cells, but is absent from T cells, null cells, red blood cells and platelets. It is found on Langerhans cells, follicular dendritic cells and histiocytes. Mo2 and MY4 antibodies were evaluated during the First International Workshop on Human Leukocyte Differentiation Antigens. RMO52 antibody was evaluated during the Third Workshop.
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Products are available FOR RESEARCH USE ONLY (RUO). Unless indicaed FOR IN VITRO DIAGNOSTIC USE (IVD)
CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories
and distributed free of charge as an educational service to the cytometry community.
If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL,
Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu
EMAIL robinson@flowcyt.cyto.purdue.edu
