CD3
T CELLS
The CD3 antigen is a complex of 5 invariable polypeptidic chains ; g, d, e, z and h whose molecular weights are respectively: 25-28, 20, 20, 16 and 22 kDa.The z chain frequently occurs in the CD3 complex as disulphide linked homodimer. CD3 is part of a bigger complex which includes the T Cell Receptor (TCR). It is expressed by mature T cells and by thymocytes. T cell activation can be induced when foreign antigen is presented to the TCR through MHC complex. These antibodies also have a mitogenic effect on T lymphocytes. They do not react with those T cells lacking the TCR. X35 and UCHT1 antibodies react with the e-chain of the CD3 complex. UCHT1 antibody was evaluated during the First International Workshop on Human Leukocyte Differentiation Antigens. X35 was evaluated during the Third Workshop.
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Products are available FOR RESEARCH USE ONLY (RUO). Unless indicaed FOR IN VITRO DIAGNOSTIC USE (IVD)
CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories
and distributed free of charge as an educational service to the cytometry community.
If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL,
Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu
EMAIL robinson@flowcyt.cyto.purdue.edu
