CD19

PAN B CELL

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
89B (B4)	FITC	50 tests	Liquid	CYTO-STAT	IVD	6603859
IgG1 (mouse)	RD1	50 tests	Liquid	CYTO-STAT	IVD	6603846
HD237 (B4 Lytic)	ECD	50 tests	Liquid	CYTO-STAT		6604551
IgG2b (mouse)				CYTO-STAT
Other mAbs

The CD19 (B4) antigen is a type I integral membrane glycoprotein with a molecular weight of 95 kDa. This molecule is expressed on all normal B cells including pre B cells, but it is lost during maturation to plasma cells. It is also found on the surface of follicular dendritic cells, on the early cells of myelomonocytic lineage and on most stabilized B cell lines. It is not present on normal T cells, NK cells, monocytes, and granulocytes. In vitro studies indicate that CD19 antibodies have an inhibitory effect on the activation and proliferation of B cells. They also inhibit the B cell response after co-stimulation by anti-immunoglobulin and Interleukin 4. B4 antibody was characterized during the Second International Workshop on Human Leukocyte Differentiation Antigens. B4 Lytic was characterized during the Third Workshop.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu