ANTICESTODAL & ANTITREMATODAL
Outline

Copyright, Purdue Research Foundation, 1996

| BMS 445 Intro | | Drug Groups | | Slides / Graphics | | Address | | E-mail | | Antiparasitics Intro. |


Chemical Groups and General Mechanisms of Anticestodal and Antitrematodal Drugs
GroupTypical DrugMechanismEffect on Parasite
Pyrazinoisoquinoline Praziquantel
Epsiprantel
Not certain
Increases membrane permeability to Ca++, but different from other ionophores
Low concentrations: Increased muscular activity, then spastic paralysis
Higher concentrations: vacuolization and vesiculation of tegument; Allows host defenses to attack
Benzenesulfonamide Clorsulon Inhibit glycolysis Energy depletion
Substituted Phenols Nitroxynil Uncouple oxidative phosphorylation Energy depletion
Salicylanilides Niclosamide
Rafoxanide1
Uncouple oxidative phosphorylation Energy depletion
Benzimidazoles Mebendazole
Oxfendazole
See Benzimidazoles, Table of antinematodals Starvation of parasite
Ovicidal
1If rafoxanide acts as other salicylanilides
Refs: Barragry'95
Webster, LT, Jr., GG8th'90
USPDI'94
Courtney & Roberson'95

Antiprotozoals -- Table

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Gordon L. Coppoc, DVM, PhD
Professor of Veterinary Pharmacology
Head, Department of Basic Medical Sciences
School of Veterinary Medicine
Purdue University
West Lafayette, IN 47907-1246
Tel: 317-494-8633Fax: 317-494-0781
Email: coppoc@vet.purdue.edu

Last modified
11:50 PM on 4/29/96 GLC