antibody to CD40L

Meenakshi Roy (meena@macsun.stanford.edu)
Thu, 10 Oct 1996 18:32:21 -0700 (PDT)

>
>From:meena@macsun.stanford.edu (Meenakshi Roy)
>Subject:antibody to CD40L
>
> MR1, an antibody to murine CD40L (which is available from Pharmingen), does
>not cross-react with human CD40L. Its detection on murine cells requires
>purification of the CD4 cells (apparently B cells can downregulate CD40L
>expressed on activated T cells), followed by activation with anti-CD3 or
>PMA/ionomycin. For information about its detection and expression, look up:
> The regulation of expression of gp39, the CD40 ligand, on normal and cloned
>CD4-positive T cells.
> Roy, M., Waldscmidt, T., Aruffo, A., Ledbetter, J.A., Noelle, R.J.
>J. Immunol, 151 (5) :2497-2510 (1993)
>

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