Re: SCID mice

Rochelle A. Diamond (diamond@cco.caltech.edu)
Mon, 23 Sep 1996 08:03:08 -0700 (PDT)

Meenakshi-
You might want to check out our paper in J. of Immunology 151:3530-3546
1993 "Functional and Phenotypic Analyisis of Thymocytes in SCID Mice"
Rothenberg et al.

We briefly mention the fact that some SCID mice can be leaky. Rag 2-/-
mice however are not known to be leaky. We are currently drafting a new
paper which is a direct comparison of SCID (2 different backgrounds) and
Rag 2-/- mice, but it is not ready to send out yet.

Best wishes,
Rochelle Diamond
Caltech Flow Cytometry/Cell Sorting Facility

On Fri, 20 Sep 1996, Meenakshi Roy wrote:

>
> Hi everyone,
> I am planning some cell transfer experiments to look at developmental
> potential of sorted T cell subsets. I am trying to weigh the
> merits/demerits of using SCID mice versus RAG deficient mice for this
> purpose.
> Does anyone have any insights on this? I would greatly appreciate your
> feedback and can undertake to post a summary on the newsgroup.
> Thanks\
> Meenakshi
>
>
>


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