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Probably the most common anti-CD59 is clone MEM-43 (an IgG2a). We have
used this mAb as well as mAb to other GPI-anchored proteins expressed on
leukocytes and characterized their expression in patients with PNH (J Clin
Invest 87:58, 1991).
JC Edberg
Cornell University Medical College
edbergj@hss.edu
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From: owner-cyto-sendout
To: Cytometry Mailing List
Subject: CD59
Date: Tuesday, June 06, 1995 5:01PM
Hello All;
We have a patient here who we suspect has paroxysmal Nocturnal
Hemoglobinuria (PNH), This disease represent a defficenty of numerous
leukocyte antigens. The PIG protein or CD59 seems to be the critical
lacking protein in these patients. While red cells are the ones most
effected by the complement, white cells also lack this protein, and thus
we can measure this by a simple flow procedure. My questions are two fold;
1. does any one out there do CD59 staining, and would you like to tell me
how I can SEND this sample to you. I really do not want to get into this
bag of worms.
2. Since no one probally does this assay in real life, where can I find CD
59. I searched all my Catalogues, and no one seems to have it. Any
pointers would wonderful.
well thanks for all the help. take care -- rr
rainer@pandoras-box.bgsm.wfu.edu
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