Fwd: using flow for B cell/plasma cell evaluation
NikitaYin@aol.com
Fri, 5 Apr 1996 20:59:30 -0500
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Forwarded message:
Subj: Re: using flow for B cell/plasma cell evaluation
Date: 96-04-05 20:49:13 EST
From: NikitaYin
To: cyto-inbox
Josh,
The examples in the paper you cited indicate CD38 intensity could be used to
identify plasma cells. Of course, it is essential to perform cytoplasmic
kappa vs. lambda light chain immunoglobulin to prove clonality in abnormal
plasma cell populations. Less than 10% of the cases of monoclonal plasma
cells match the CD38 expression on lymphoblasts (in cases of plasma cell
leukemia), and in these instances, other criteria such as CD45 and light
scatter could be used to distinguish the cells. As you know, the definition
of complex populations by a single parameter is dangerous at best.
Denise A. Wells, M.D.
CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories
and distributed free of charge as an educational service to the cytometry community.
If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL,
Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu
EMAIL robinson@flowcyt.cyto.purdue.edu
