We had a bone marrow from a patient with a large percentage ( 60 % ) of blasts in the peripheral blood ( 82 yr F ). There were two populations of interest. An agranular CD45 dim population and an more granular CD45 dim population. The phenotype of the agranular population ( 50% ) was CD5, CD7, CD13, CD34, TdT positive and negative for all other T, B, Myeloid markers. The more granular population was positive for CD7 CD33, CD13, HLA-DR, CD34, CD11b ( dim ), TdT and MPO ( as before negative for all other markers ). I'd be interested in the opinion of others. We are thinking AML with maturation and with ectopic T marker expression. I put a GIF with relevant dotplots at http://www.nyct.net/~brentd/flow/Final.gif Thanks, Brent Dorsett Lenox Hill Hospital --- NYC
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