Re: Antibodies for malignant plasma cells

From: Mariano Scolnik (mscolnik@hematologia.anm.edu.ar)
Date: Tue Dec 04 2001 - 06:35:24 EST


El 30/11/01 18:03, "Andrea Illingworth" <dcdsflow@mint.net> escribió:

> Dear group,
> What are your thoughts on the use of CD40 to differentiate normal plasma cells
> from myeloma cells?
> Currently we are using the CD45/CD56/CD38 combination but we are looking into
> either adding CD138 and/or CD40. Would you recommend one over the other or
> recommend adding both antibodies?
>  
> Thank you for your input!
>  
> Andrea Illingworth
> Dahl-Chase Flow Cytometry
> Bangor, Maine 04401
> Andrea_Illingworth@dahlchase.com
>  
> Dear Andrea:
> In our lab we are using CD19 and CD138 to differentiate normal plasma cells
> and myeloma cells. The combinations are: CD38/CD138/CD45, CD38/CD56/CD19,
> CD54/CD20/CD56 and cytoplasmic Kappa/Lambda in combination with CD38 or CD138.
> Usually we don´t have problems to distinguish normal and abnormal plasma
> cells.
> Actually we using CD138 performed by Immuno Qualyty Products Cat. Number
> IQP142F (FITC) and IQP142R (PE)
> Best wishes
> 
Dr. Mariano P. Scolnik
IO/IIHEMA
Academia Nacional de Medicina
Pacheco de Melo 3081 (1425)
Buenos Aires 
Argentina
Tel: (54-1) 4805-5759 Ext 289
FAX  (54-1) 4803-9475

 
>  
> 
> 



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