Re: Beads and apoptosis

From: russ w (russ1900@hotmail.com)
Date: Tue Aug 28 2001 - 16:24:09 EST

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 >Does anybody know whether the HLA-DQ molecule has any association with
>apoptosis?
>We use the Dynal Dynabeads to isolate B cells for microlymphocytoxicity
>reactions and have noticed an abnormally higher (dead cell) background.
>One thought put to me was that the beads attached to the DQ molecule may
> >initiate apoptosis.
>Any thoughts?

Nick
Dynal beads used in HLA microlymphocytotocity testing binds to CD19+ cells.
It can not interreact with the HLA DQ loci because that is one of the
antigens we test for when we do HLA DR/DQ typing.

Russ Wick MT(ASCP)SBB




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