Hi All, I have an unusual situation. I have been looking at a range of congenic rats and have found that the vascular smooth muscle cells seem to be aneuploid. The profile is normal at the 1N and there is a leak about 1.2N and a large spread at G2M (maybe 2 populations). I have ran a large number of tumor samples in the past and this profile shows great similarity to a number of them. The rats are otherwise normal apart from this unusual DNA profile . Has anyone any idea what could be reason for this unusual DNA profile? Best wishes James
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