Re: Do PI concentrations vary for measuring cell viabilityandDNAanalysis???

From: Ana Salas (ana@lupo.medicina.uniovi.es)
Date: Mon Jun 25 2001 - 03:39:45 EST


Dear Mark,
Thank you for your recommendations, I will take them into account. I was following
the reference: Detergent and proteolytic enzyme-based techniques for
nuclear isolation and DNA content analysis.In: Methods in cell biology, Volume 41 Flow
Cytometry, 2nd edition, part A. 1994. Lars L. Vindelov and Ib Jarle
Christensen. I will try with lower concentrations of IP in order to improve my CVs
(now about 4% for solid tissues).
Ana

Mark Kukuruga escribió:

> Ana,
> I think you should re-check that . . . every reference I've looked at for Vindelov's
(as I just did . . .) indicates 50 ug/ml as the PI concentration.
> Also, I've analyzed cells stained at PI concentrations above 50 . . . the PI signal
starts to drop at about 80 ug/ml, and %c.v. increases dramatically.
> Finally . . . we use PI to exclude dead cells in extended sorts . . . little toxic
effect is evident.
> MAK.
>
> --
> Mark A. KuKuruga, Managing Director
> University of Michigan Flow Core
> 7416 CCGC 0946
> (734) 647-3216, fax (734) 936-7376
> kukuru@umich.edu
>
> >>> Ana Salas <ana@spi.uniovi.es> 06/22/01 05:08AM >>>
> Hello everbody,
> When you are measuring cell cycle with the intercalating dye IP you must be sure
that the
> concentration is in great excess to saturate all nuclei. Then, you should wait for 10
> minutes to obtain an equilibrium between IP inside and the solution and then you
can make
> the adquisition.  If cell concentration is too high is not possible to became
stoichiometric
> join IP-DNA. In Vindelov protocol IP concentration (for uniparametric analysis)
is about 140
> ug/ml for 1 million of cells.
> When you want to measure cell viability with IP the concentration of cells and time
is also
> important. The concentration should be under 1ug/ml (for 1 million of cells) and the
> adquisition should be make inmediately to avoid cells to die due to the toxic effect
of the
> IP.
> Chao
>
> Ana Salas
> Servicio científico-técnico de Citometria
> Universidad de Oviedo.Spain
>
> Mark Kukuruga escribió:
>
> > Rana,
> > PI stains double-stranded nucleic acids.  If we want to resolve cell cycle
compartments,
> > we typically use 20-50 ug/ml (I've gone as low as 10) as a staining concentration.
> > If you do the comparison, you'll find that this relatively broad range will yield
> > comparable results.  Much higher, and you start to lose resolution . . . lower,
and you
> > may no longer be stoichiometric . . . i.e., you may not stain all cells as uniformly
> > as you'd like, and G1/G2M ratios will suffer.  50 ug/ml is an accepted concentration
> > for cell cycle staining.
> > However, if all you need is a viability marker, add just enough to resolve live
> > from dead.  And, since this measurement is usually done log amplified, only a little
> > is needed.
> > There are applications where sub-optimal PI concentrations are necessary.  If, for
> > example, you want to look at other nucleic acid-associated markers (say, incorporated
> > BrdU, or some DNA associated protein) with green fluorescent dyes - - like FITC -
> > - , you may actually quench your signal with too much PI.  Here, stoichiometry is
> > sacrificed for green signal resolution . . . in this case, all you want is a G1 and
> > G2M position indicator, and 1 to 5 ug/ml PI will accomplish that.
> > Adding lower amounts of PI will better allow simultaneous analysis of phycoerythrin
> > conjugates . . . signal crossover is far more manageable.
> > Adding low amounts also helps with visualizing co-stains via microscopy.  If, for
> > example, you want to look at PI versus some green fluorescent marker . . . too much
> > PI will overwhelm/mask the green signal.
> > Bottom line . . . use the concentration that's appropriate for the application.
> > 50 ug/ml is a standard for cell cycle.  Other applications may require changes in
> > this empirically defined optimal concentration.  Using PI at 1 ug/ml (or even less)
> > will work as a viability indicator.
> > MAK.
> >
> > --
> > Mark A. KuKuruga, Managing Director
> > University of Michigan Flow Core
> > 7416 CCGC 0946
> > (734) 647-3216, fax (734) 936-7376
> > kukuru@umich.edu
> >
> > >>> Rana Nagarkatti <rana_nagarkatti@usa.net> 06/19/01 05:06PM >>>
> >
> > Dear Group,
> >  I was wondering if the above queston is actually true. The reason being that
> > I had done some calculations regarding the final conc of PI in various
> > protocols used for Viability and DNA analysis. and found that ususally for DNA
> > 50ug/ml is the required conc ( for Flow- may be to maintain equilibrium in the
> > stream etc but any ideas for fluorimetry???)and for viability it is around
> > 1ug/ml. What is the reason? Do higher conc of PI in the staining buffer mean
> > that more PI will enter the cells or is the cell totally impermeable to the
> > PI. or that the PI conc used for viability has been standardized based on a
> > concurrent experiment with say trypan blue or other methods? And how does time
> > of incubation after adding the dye relate to the conc. After all both the
> > methods are based on the same prinnciple that PI binds to DNA. Are there any
> > simple proportionalities involved here eg more the dye less the time or mmore
> > the dye more enters into the cells etc.
> > Thanks in advance for all the tips.
> > Rana Nagarkatti
> >
> > ____________________________________________________________________
> > Get free email and a permanent address at http://www.netaddress.com/?N=1



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