Re: Fish cells

From: janet dow (jldow@unity.ncsu.edu)
Date: Mon Apr 30 2001 - 09:52:40 EST


>I have done some work in this area and it is very straightforward flow.
>The cells from blood are very similar in size to other animals-especially
>feline and pig blood.  You may have to make some adjustments in the
>forward scatter and they may be  more granuular then you are use to.  Make
>sure to to fine out from the researcher exactly what you are looking
>for-my people look for macrophages and they are very granular in fish.  I
>also believe my researchers use 2% freshly made paraformaldehyde to fix
>the cells and then stain for PI.    I will dig through my data banks and
>look for examples to send to you.  I work on BD machines, FACSCalibur and
>FACScan.   Hope this helps.
>
>good luck.
>
>Janet Dow
>
>
>
>
>>Fish cells.
>>
>>This is a new area for me.  Does anybody have any data files to look at or
>>protocols to use for the fixing of fish cells to stain with PI when looking
>>at the DNA content of the cells.  It would be nice to know what I should be
>>looking at and the gating strayegies to achieve the cell cycle profile.
>>
>>Any help or direction would be appreciated.
>>
>>Andy
>
>
>

Janet Dow
Research Technician and Manager
Flow Cytometry Facility
North Carolina State College of Veterinary Medicine
Room C-314
Raleigh, NC 27606
(919)513-6364



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