Chris This is very unusual... after discounting technical staining and cytometric issues, I agree with your first idea that this most closely seems like a LGL. However, I would be curious to know if you had the opportunity to assess more mono/myeloid markers, such as CD13,33, MPO etc ?... I have seen the markers you indicate rarely coexpressed [especially and unusually CD3 with CD19] on AML blasts. F Preffer At 01:22 PM 3/19/01 -0600, Bee, Christopher wrote: > >We recently received a peripheral blood sample on an 80 year old gentleman >with mild leukocytosis and an absolute lymphocytosis (WBC-13,700/ul, 70% >lymphocytes). Many of the lymphocytes had the morphology of LGLs. The >lymphocytes showed expression of CD8, CD3, CD7, CD11c and CD16 without >significant expression of CD4, CD2 or CD5. The phenotype is good for the >T-cell type of LGL. Interestingly, the cells also showed relatively bright >expression of CD19. I found a couple of case reports describing similar >cases with CD20 but not with CD19. Has anyone else seen this in their >personal experience or documented in the literature? Thanks in advance for >your input. > > >Christopher S. Bee, M.D. >Medical Director, Cellular Immunology and Flow Cytometry >Wilford Hall Medical Center >Lackland AFB, Texas >(210) 292-5455 >DSN 554-5455 >christopher.bee@59mdw.whmc.af.mil > Frederic I. Preffer Department of Pathology Charlestown Navy Yard- 7140 Massachusetts General Hospital East Charlestown, MA 02129 voice [617] 726-7481 fax [617] 724-3164
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