ALPS is Autoimmune LymphoProliferative Syndrome. See reference below Lim, M. S., Straus, S. E., Dale, J. K., Fleisher, T., Stetler-Stevenson, M, ., Strober, W., Sneller, M. C., Puck, J. M., Lenardo, M. J., Elenitoba-Johnson, K. S. J., Lin, A. Y., Raffeld, M., and Jaffe, E.: Pathologic findings in human autoimmune lymphoproliferative syndrome. Am. J. Pathol. 153:1541-1550, 1998. > What is ALPS? > >Tim Singleton > > >>> "Dr. Martin R. Hadam" <Hadam.Martin@mh-hannover.de> 03/09/01 04:28PM >>> > >On Thu, 8 Mar 2001 18:15:43 -0500, Maryalice Stetler-Stevenson wrote: > > >We recently had an ALPS patient (20yo, lymph adenopathy) lymph node > >FNA with a high number of homogeneous abnormal T cells- 64% CD3+, > >CD2+, CD5+, CD7-, CD57+, CD38+, CD4-, CD8- and CD25-. I thought this > >was very high numbers and was concerned abouyt a developing lymphoma > >(they do get them you know, and besides, tumors happen). Has anyone > >ever seen this high a % homogeneous abnormal T's in ALPS before? > > Yes, even in peripheral blood (but you sure need to watch out for >developing malignancies). What I find even more interesting is that the >cells in your patient are also CD7-negative; such data are rarely >provided if ever. I've seen this phenotype in two (pediatric) cases. >Seems to me that the marker combination CD3+CD4-CD7-CD8- lends itself >to readily detect such a subset even when occurring with less abundance >e.g. in peripheral blood. CD7 could then be used to differentiate from >"normal" double-negatives. > > > Martin R. Hadam > Kinderklinik - Medizinische Hochschule > D-30623 Hannover > Germany > Email: Hadam.Martin@MH-Hannover.de Maryalice Stetler-Stevenson Director Flow Cytometry Unit Laboratory of Pathology, NCI, NIH "Learn the rules so you know how to break them properly." The Dalai Lama
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