What is ALPS? Tim Singleton >>> "Dr. Martin R. Hadam" <Hadam.Martin@mh-hannover.de> 03/09/01 04:28PM >>> On Thu, 8 Mar 2001 18:15:43 -0500, Maryalice Stetler-Stevenson wrote: >We recently had an ALPS patient (20yo, lymph adenopathy) lymph node >FNA with a high number of homogeneous abnormal T cells- 64% CD3+, >CD2+, CD5+, CD7-, CD57+, CD38+, CD4-, CD8- and CD25-. I thought this >was very high numbers and was concerned abouyt a developing lymphoma >(they do get them you know, and besides, tumors happen). Has anyone >ever seen this high a % homogeneous abnormal T's in ALPS before? Yes, even in peripheral blood (but you sure need to watch out for developing malignancies). What I find even more interesting is that the cells in your patient are also CD7-negative; such data are rarely provided if ever. I've seen this phenotype in two (pediatric) cases. Seems to me that the marker combination CD3+CD4-CD7-CD8- lends itself to readily detect such a subset even when occurring with less abundance e.g. in peripheral blood. CD7 could then be used to differentiate from "normal" double-negatives. Martin R. Hadam Kinderklinik - Medizinische Hochschule D-30623 Hannover Germany Email: Hadam.Martin@MH-Hannover.de
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