Hi flowers, Thanks so much for responding to my initial question on the id of CD34+CD19+ cells (by the way, my observation has been in BM and mobilized PBPCs). It made me further question the significance of this presence. Say, a patient was infused with stem cells that were primarily committed to B-cells (b-cell precursors). Would it have any clinical significance on the engraftment outcome? What if these stem cells were primarily CD34+CD33+; Would the clinical outcome of the patient be different from the patient who received primarily CD34+CD19+ cells? Or, what if there was an equal distribution of both, CD34+CD19+ and CD34+CD33+? Does the stimulation regimen (G-CSF) for mobilizing stem cells play a role in the choice of the stem cell differentiation pathway? Yet again, I have seen this in Bone Marrow where there has been no stimulation at all. Any takers? Thanks again for your time, Liza Liza McGuire Bone Marrow Transplant Laboratory, Supervisor Thomas Jefferson University Hospital 130 S 9th Street, Rm. 400 Edison Philadelphia, PA 19107-5233 (215)955-9646
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