Greetings Dirk, We often see a fair number of CD10+ B-cells in samples isolated from lymph nodes in which there is no apparent lymphoma. The percentage is highly variable, from a few percent to as high as 25-30% of the lymphocytes. These cells are polyclonal based on light chain expression. They typically express more CD20 than their CD10 negative counterparts and are usually negative for CD24. We have assumed that these cells are probably "normal" follicular B-cells. Tom Sawyer MCO Flow Cytometry Lab Toledo, OH 419.383.4212 >>> "PD Dr. Dirk Behringer" <behringer@mm11.ukl.uni-freiburg.de> 01/18/01 06:19AM >>> High, does anybody have data on the regular expression of CD10 in lymph node aspirates? We rarely have seen CD10+ B cells in diseases other than follicular or high grade B-cell lymphoma. Any information highly appreciated. Kind regards Dirk Dirk Behringer (behringer@mm11.ukl.uni-freiburg.de) Medizin I, Studienzentrale, Universitätsklinik Freiburg, Hugstetterstr. 55, 79106 Freiburg Tel: 0761-270 3505; FAX: 0761-2703684
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