Dear all, in my view, the best source of information on the surface expression of leukocyte antigens is the result of HLDA workshops. For years I have been using an excellent LDAD database written by Steve Shaw (he is also a founder of PROW). It runs under MS-DOS and contains data coming from the blind panel analysis during 5th HLDA WS in Boston, 1993. You can download it from: ftp://ncbi.nlm.nih.gov/pub/shaw/LDAD/ldad1.zip Of course, it contains only a limited set of cell types and CD molecules up to CD130. Similar data have been obtained also in the 6th HLDA WS and have been published on the web (different cell types, molecules up to CD166): http://mol.genes.nig.ac.jp/hlda/ but unfortunately are not accessible today. Does anyone out there know what happens to that valuable source of information? The B cell section has its own web site at: http://phoenix.jr2.ox.ac.uk/BcellWork/Bcell.html Unfortunately, no blind panel analysis or general data evaluation has been done during 7th WS and therefore we have no information on the new CD167-CD247 molecules' expression. Most of them are already known under alternate names, but their expression has not been studied extensively. Hopefully, some data will be published in the workshop book. Atilla Dagdeviren has recently set up a web site containing data from tissue section studies: http://imaging1.ouhsc.edu/attila/ All these attempts are of course very incomplete and in the future only those which contain general expression data (not only leukocyte specific) and which are able to automatically incorporate and evaluate/annotate new data from recent studies will be most valuable. Today the major resources are already linked together, mostly at NCBI: LocusLink: http://www.ncbi.nlm.nih.gov/LocusLink/ OMIM: http://www.ncbi.nlm.nih.gov/Omim/ PROW: http://www.ncbi.nlm.nih.gov/prow/ SAGE: http://www.ncbi.nlm.nih.gov/SAGE/ GeneCards: http://bioinformatics.weizmann.ac.il/cards/ Ensembl: http://www.ensembl.org/ With the introduction of large-scale screening techniques, like microarray gene-chips or proteomics/mass spectrometry, we will be for sure facing the problems to incorporate such enormous amount of data into generally accessible databases. Does anyone know about other attempts to collect expression data than those mentioned above? ;-) Karel Drbal Institute for Immunology Vienna International Research Cooperation Center University of Vienna Robert.D.Nelson@healthpartners.com wrote: > > from robert.d.nelson@healthpartners.com > Regions Hospital, St. Paul, MN > > Am looking for a web site that list the cd antigens and the cell(s) expressing > each antigen. Have spent several hours trying to avoid having to make this > request. You may inform me directly, unless you feel that this information > would be helpful to the cytometry public. Help and thanks.
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