Dear Juan, You really need morphological correlation. If they are blastic in appearance then this is an immunophenotype for T-cell ALL. However, we have had many sezary syndromes and adult T cell leukemia/lymphoma associated with HTLV-1. Occasionally they are CD3- and they can be CD4+/CD8+. It is rare, but this type of immunophenotype does occur in more mature T cell neoplasms. Also, how many cells are we talking about? In severely ill or immunocompromised patients you can sometimes detect low level immature T-cells in the periphery- usually they are so ill they are on their death bed. Statistically speaking, my money is with the T-cell ALL, but you need to correlate with morphology and clinical history before final diagnosis. Let us know follow up. Maryalice >I have blood of a patient, 21 years, male. There are a population of >litlle cells (low FSC, low SSC) and low expresion of CD45 (Tipical >region for B leukemias) >The sample are CD19(-), CD20(-), CD10(-), CD34(-),CD13(-), >CD33(-),HLA-DR(-), CD16(-), CD56(-), CD3(-), CD4(+), CD8(+), CD2(-), >CD7(+), CD5 dim. >The mieloperoxidase is more brigth that the normal population, but >more dim that the granulocytes populations ???? >I think that is T leukemia, but I donīt have much experience with T >dissorders. In my country, Chile, principally we see LLA-B >Any idea >-- >JUAN LUIS CASTILLO N. >CITOMETRIA DE FLUJO >HOSPITAL DEL TRABAJADOR >CARDENIO AVELLO 36 >CONCEPCION >CHILE: >PHONE: 56-41-402138 >56-41-329454 >FAX: 56-41-402117 >E- MAIL: <mailto:axelyoyi@entelchile.net>axelyoyi@entelchile.net ><http://oncoinmun.bizland.com>http://oncoinmun.bizland.com > > Maryalice Stetler-Stevenson Director Flow Cytometry Unit Laboratory of Pathology, NCI, NIH
This archive was generated by hypermail 2b29 : Sat Mar 10 2001 - 19:31:36 EST