Re: Please help: which anti-CD10 clones work well on lymph nodes ?

From: astacchini@molinette.piemonte.it
Date: Mon Jan 28 2002 - 03:38:09 EST


Jáksó Pál <Pal.Jakso@aok.pte.hu> ha detto:

>  I get good results wihh CD10 Pe Caltag clone 5-1B4 or CD10 Fitc Coulter
clone J5. See on purpose Am J Clin Pathol 2001;116:183-190
> Dear flowers,
>
> One of our pathologists complained about our CD10 flow results of lymph
> node biopsies and fine needle aspirates, because they don't match with
> immuohistochemical staining which shows positivity of lymph nodes
> germinal center cells and follicular lymphoma while the flow shows
> negativity or very dim stain although this antibody works well in B-cell
> acut lymphoid leikaemia. Currently we use DAKO (clone: SS2/36) for flow
> and Novocastra CD10 (clone: 56C6) for immunohistochemistry. I think  the
> different clones may give different staining.
> Novocastra does not produce fluorescent labelled CD10 for flow and I
> have to look for other sources to try different CD10 clones wich give
> comparable result with the immunohistochemistry in the case of lymph
> nodes.
> Has anybody experience on this ?
>
> Thanks,
>
> Pal Jakso
>
> University of Pecs
> Faculty of Medicine
> Dept. of Pathology
> 7643, Hungary
> 12. Szigeti str.
>



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