Re: Quantitative PCR & Housekeeping Genes

From: Tony Schountz (tschount@mesastate.edu)
Date: Tue Jun 06 2000 - 15:06:32 EST


Mario Roederer wrote:

> Hi, a little off the flow topic (but only a little)....
>
> we are doing quantitative PCR on very small numbers of sorted cells,
> and are looking around for a different housekeeping gene for control
> purposes than beta-actin.  We need one with an intron so that we can
> differentiate cDNA from genomic in our ultrasensitive amplifications.

Since you're using PCR, just design your primers so they span adjacent
exons. This way, genomic DNA won't amplify and your only signal will be
the cDNAs.

--
Tony Schountz, Ph.D.
Department of Biological Sciences
Mesa State College
mailto:tschount@mesastate.edu



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