Unusual B cell morphology
From: Michelle Fiordalisi (Fiordam@labcorp.com)
Date: Fri Oct 01 1999 - 13:38:37 EST
attached mail follows:
Date: Fri, 01 Oct 1999 12:36:02 -0400
From: "Margaret Johnson" <johnsonm@labcorp.com>
To: cyto-inbox
Subject: Cytometry Users Group Message
Mime-Version: 1.0
Content-Type: text/plain; charset=US-ASCII
Content-Transfer-Encoding: quoted-printable
Content-Disposition: inline
Has anyone seen this before?
75 yo woman, WBC 31,000. Splenomegaly.=20
Morphology: Homogeneous population of large cells with round nuclei and a =
single large nucleolus, clumped chromatin, faint pink granules in the =
cytoplasm.=20
Light scatter: Cells are larger than lymphocytes and monocytes and have =
side scatter like granular myeloblasts.
Phenotype:
Positive CD19, CD20 (bright), CD22, CD10(dim), HLA-DR, FMC-7, kappa =
surface expression (bright), CD45 (from as bright as normal lymohocytes to =
slightly dimmer)
Negative: CD23, CD5, CD11c, CD34, CD13, CD33, CD14, all pan T.=20
The phenotype is consistent with a B cell lymphoproliferative disorder =
however the granular cytoplasm seen both on Wright's stain and by light =
scatter is very atypical. The ordering physician thought it was AML. =
Anyone seen granular B-cell prolymphocytes or lymphoma?
This archive was generated by hypermail 2b29
: Wed Apr 03 2002 - 11:54:02 EST