Maryalice,
I am aware of two older series looking at CD57 expression in T lymphoblastic
lymphoma. They describe a total of nine cases that are positive and are Kaplan
et al. Am J Hematol 1986;22:355, and Shebani et al. Cancer 1987;60:183. I am
not sure if they were studied for CD56.
We no longer do CD57 routinely on acute leukemias, but our recent experience is
that 6% of our ALLs are CD56 positive.
Dan Arber
City of Hope
____________________Reply Separator____________________
Subject: interesting case
Author: Maryalice Stetler-Stevenson <stetler@box-s.nih.gov>
Date: 9/9/99 2:38 PM
We have an interesting case of a pleural fluid from a patient with
a questionable diagnosis of T-cell lymphoblastic lymphoma (relapsed 6
months post treatment). No additional history available. The cells are
surface CD3+, CD4+, CD8+, CD7+, CD2+, CD5+, CD38+, CD56+, CD57+, TCR alpha
beta +, CD25-, CD16- CD34- and dim CD10. No B-cell antigens. The CD57+ and
CD56+ seems strange for lymphoblastic lymphoma. Anyone have experience with
these antigens in lymphoblastic lymphoma? Unfortunately the correct history
came long after the specimen and we were told a mature T-cell lymphoma so
the TDT was not done. We are trying to get more material for a TDT. Anyone
seen this before?
Maryalice Stetler-Stevenson
and
Doug Kingma
Maryalice Stetler-Stevenson
Director Flow Cytometry Unit
Laboratory of Pathology, NCI, NIH
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