Wladyslaw,
CD162 is the ligand for P-selectin (CD62P); so yes you will get platelet
adhesion...read
Andrews, R.K. Molecular Mechanisms of Platelet Adhesion and Activation.
Int.J.Biochem.Cell Bio. 29(1):91-105, 1997.
Furie, B. and Furie, B.C. The molecular basis of platelet and endothelial
cell interaction with neutrophils and monocytes: role of P-selectin and the
P-selectin ligand, PSGL-1. Thromb Haemost 74(1):224-227, 1995.
Elstad, M.R., McIntyre, T.M., Prescott, S.M., and Zimmerman, G.A. The
interaction of leukocytes with platelets in blood coagulation.
Curr.Op.Hematol. 2:47-54, 1995.
To get started...................You'll find CD162 (PSGL-1) on any bllod
cell that has reason to exvasate by all accounts. I have read studies on
monocytes and Neutrophils, (which is my interest) and also on T cells.
CD62P is also expressed on TNF alpha stimulated endothelial cells. Work on
which suggest there may be some overlap in ligand binding by all the
selectins.
Hope this helps
Craig.
From: mmpajdak@cyf-kr.edu.pl
To: cyto-inbox
Subject: CD162
Date: 09 September 1999 09:29
Dear All,
Does anyone have experience and/or information on CD162 ?
(Which cells are CD162+ ? Any role in platelet adhesion ?).
Thanks in advance,
wp
*************************************************************
Wladyslaw Pajdak
Department of Clinical Immunochemistry,
Internal Medicine II, Collegium Medicum,
Jgiellonian University
Skawinska 8, 31-066 Cracow, Poland
Tel: (+4812)656 54 25, Fax: (+4812)656 57 86
E-mail: mmpajdak@cyf-kr.edu.pl
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