RBC lysis

From: Johnson, Flavia (Flavia.Johnson@wl.com)
Date: Fri Jul 30 1999 - 12:03:02 EST


Hi!

First of all, I'd like to thank all who have responded to my email about
rabbit monocyte marker. It was well appreciated!

I am having trouble to differentiate rabbit heterophils from monocytes in
the light scatter plot of a hematology counter. The heterophils are as large
as the monocyte, and the nucleus can be tight and compact, similar to that
of a monocyte. They differ in that heterophils have small granules in the
cytoplasm. So, I usually obtain a population of cells with higher
granularity in the mononuclear gate of a 90o/10o plot. As a result,
heterophils are counted as monocytes and I get innacurate percentages of the
cell populations.
Does anybody have experience with rabbit cells? How could I differentiate
the two populations without overlap?

Thanks!



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