Ca++ flux experiments

From: Nthale, Joseph (J.NTHALE@CGIAR.ORG)
Date: Wed Jul 21 1999 - 02:18:40 EST


Dear Flowers,

We plan to start Ca++ determinations on a 488 laser.  We will use the assay
system to determine the capacity of synthetic peptides to "block" Ca++ flux
induction by suboptimal amounts of stimulating CD21 antibody on bovine PBMC.
It a long time since we did Ca++ experiments using Fluo-3, and, obviously,
science has moved on.  Could someone out there recommend a working protocol
for Fluo-3 as well as Fluo 3 vs Fura Red Fluo pointing out the merits and
demerits of each approach if possible?  In our hands, Fluo-3 worked well.
We intend to use the same reagents which have been stored at -20oC over the
years.  Would it be advisable to order fresh reagents or will the "old"
work?  Your experiences will be treasured.  Thank you in advance.  Joseph  




********************************************************
Joseph Nthale
Genetics of Disease Resistance (GDR)
ILRI -International Livestock Research Institute,
E-Mail: J.Nthale@cgiar.org
Phone: +254-2-630743
Fax: +254-2-631499
P.O. Box 30709, Nairobi, Kenya
> Visit the ILRI web site at http://www.cgiar.org/ilri
********************************************************
Future Harvest
ILRI is one of 16 international agricultural research institutes supported
by the Consultative Group on International Agricultural Research (CGIAR).



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