Cytokine Activation

From: Echeagaray, Patricia L. (echeagaray@serquest.com)
Date: Mon Jul 12 1999 - 09:53:35 EST


Greetings!

I am trying to stain for intracellular IFN-gamma and IL-4 in rhesus. Does
anyone have any suggestions as to concentration of PMA and ionomycin which
work as activators? 

This activation step is not done in flasks, but is activation of 100 ul
whole blood (plus 100 ul of tissue culture media therfore a total volume of
200 ul). I tried to activate 24 hours and got absolutely nothing! (These are
however, normal cells, and I only used IFN -gamma this time as the IL-4 is
normally lower....or so I was told)



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