Re: Dual Laser sorting/FRET

From: Dr S Sreckovic (Sasa.Sreckovic@bristol.ac.uk)
Date: Thu Jul 08 1999 - 12:46:52 EST


Hi Ann,

You should always calculate drop delay from the laser that gives you a 
threshold signal which is usually 488 nm giving FSC as threshold. 
Interception with this laser beam is when detection process starts in 
time and is followed by sorting decision which are both calculated in 
delay time. Using 2-nd laser spot, you've calculated shorter drop delay
which probably worked OK, especially with larger sort envelope.

Regards,
Sasha

On Wed, 7 Jul 1999 16:14:03 +0000 Ann Atzberger 
<Ann.Atzberger@EMBL-Heidelberg.de> wrote:

> 
> Hallo Flowbies, (I hope that's not a rude word)
> 
> 2 Questions:FACS Vantage
> 
> 1. When sorting with dual laser does one calculate the drop delay from the
> 2nd laser spot or from the first?. I've been using the 2nd and sorting
> seems to be o.k (haven't checked recovery) but someone else I know
> calculates from the 1st.
> 
> 2. When doing FRET analysis should the laser with the lower wavelength
> always be in position 1?
> 
> Haven't been able to find anything regarding the above anywhere.
> 
> 
> slainte
> 
> Ann
> EMBL
> Heidelberg
> 
> 

----------------------
Dr Sasha Sreckovic
Dept Path & Micro
University of Bristol
University Walk
Bristol, BS8 1TD, UK
Sasa.Sreckovic@bristol.ac.uk
0117-928-8606



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